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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HIBCH
All Species:
23.64
Human Site:
S378
Identified Species:
37.14
UniProt:
Q6NVY1
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6NVY1
NP_055177.2
386
43482
S378
D
L
N
N
H
F
K
S
L
G
S
S
D
L
K
Chimpanzee
Pan troglodytes
XP_515988
440
48807
S432
D
L
N
N
H
F
K
S
L
G
S
S
D
L
K
Rhesus Macaque
Macaca mulatta
XP_001103467
444
49874
S436
D
L
N
N
H
F
K
S
L
G
S
N
D
L
K
Dog
Lupus familis
XP_848689
359
39946
L352
L
N
N
Y
F
K
P
L
G
S
N
D
L
K
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZS1
385
43019
S377
D
L
N
S
Y
F
K
S
L
G
S
S
D
L
K
Rat
Rattus norvegicus
Q5XIE6
385
43006
S377
D
L
N
S
Y
F
K
S
L
G
S
R
D
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJ60
385
42810
P377
F
V
D
N
C
F
K
P
L
G
N
N
D
L
K
Frog
Xenopus laevis
A2VDC2
385
42348
S377
Y
I
D
S
C
F
T
S
L
G
S
R
D
L
K
Zebra Danio
Brachydanio rerio
Q58EB4
382
42258
S374
F
V
D
K
C
F
S
S
L
D
E
R
D
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650453
385
42729
K376
H
V
Q
W
F
F
R
K
L
P
D
T
E
E
L
Honey Bee
Apis mellifera
XP_396249
396
44074
L378
Y
I
N
Q
Q
F
N
L
L
T
N
E
L
H
S
Nematode Worm
Caenorhab. elegans
P34559
288
31153
R281
M
T
A
F
A
E
K
R
K
P
Q
W
E
S
K
Sea Urchin
Strong. purpuratus
XP_791196
379
41899
P371
I
V
T
S
H
F
R
P
L
G
K
Q
E
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q1PEY5
378
42237
N368
L
K
F
P
P
R
N
N
L
P
A
L
A
I
A
Baker's Yeast
Sacchar. cerevisiae
P28817
500
56270
N467
E
V
L
N
H
F
A
N
V
I
P
S
R
R
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.8
84.9
84.4
N.A.
81.8
81.6
N.A.
N.A.
69.1
69.6
65.2
N.A.
49.2
47.9
24.6
56.9
Protein Similarity:
100
86.8
86.2
87.8
N.A.
92.2
92.2
N.A.
N.A.
83.9
81.3
78.2
N.A.
67.6
67.1
40.9
75.1
P-Site Identity:
100
100
93.3
6.6
N.A.
86.6
80
N.A.
N.A.
53.3
53.3
40
N.A.
13.3
20
13.3
33.3
P-Site Similarity:
100
100
100
13.3
N.A.
100
93.3
N.A.
N.A.
80
73.3
53.3
N.A.
40
33.3
20
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
39.1
30.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.8
47
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
0
7
0
0
0
7
0
7
0
7
% A
% Cys:
0
0
0
0
20
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
34
0
20
0
0
0
0
0
0
7
7
7
54
0
0
% D
% Glu:
7
0
0
0
0
7
0
0
0
0
7
7
20
7
0
% E
% Phe:
14
0
7
7
14
80
0
0
0
0
0
0
0
0
7
% F
% Gly:
0
0
0
0
0
0
0
0
7
54
0
0
0
0
7
% G
% His:
7
0
0
0
34
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
7
14
0
0
0
0
0
0
0
7
0
0
0
7
0
% I
% Lys:
0
7
0
7
0
7
47
7
7
0
7
0
0
7
60
% K
% Leu:
14
34
7
0
0
0
0
14
80
0
0
7
14
60
14
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
47
34
0
0
14
14
0
0
20
14
0
0
0
% N
% Pro:
0
0
0
7
7
0
7
14
0
20
7
0
0
0
0
% P
% Gln:
0
0
7
7
7
0
0
0
0
0
7
7
0
0
0
% Q
% Arg:
0
0
0
0
0
7
14
7
0
0
0
20
7
7
0
% R
% Ser:
0
0
0
27
0
0
7
47
0
7
40
27
0
7
7
% S
% Thr:
0
7
7
0
0
0
7
0
0
7
0
7
0
0
0
% T
% Val:
0
34
0
0
0
0
0
0
7
0
0
0
0
0
0
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
14
0
0
7
14
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _